Featured Publications

Wu MT and D’Souza VM (2020). Alternate RNA Structures. Cold Spring Harb. Perspect. Biol. 12.

Pham VV, Salguero C, Khan SN, Meagher JL, Brown WC, Humbert N, de Rocquigny H, Smith JL, D’Souza VM (2018). HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry. Nature Communications 9. Departmental Feature.

Imai S, Kumar P, Hellen CU, D’Souza VM, Wagner G (2016). An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation. Nature Structural & Molecular Biology 23, 859-864.

Longhini AP, LeBlanc RM, Becette O, Salguero C, Wunderlich CH, Johnson BA, D’Souza VM, Kreutz C, Dayie TK (2016). Chemo-enzymatic synthesis of site-specific isotopically labeled nucleotides for use in NMR resonance assignment, dynamics and structural characterizations. Nucleic Acids Res. 44, e52.

Miller S, Yildiz FZ, Wang B, Lo J, D’Souza VM (2014). A structure-based mechanism for tRNA and retroviral RNA remodelling during primer annealing. Nature 515, 591-5.

Alvarado LJ, LeBlanc RM, Longhini AP, Keane SC, Jain N, Yildiz ZF, Tolbert BS, D’Souza VM, Summers MF, Kreutz C, Dayie TK (2014). Regio-selective chemical-enzymatic synthesis of pyrimidine nucleotides facilitates RNA structure and dynamics studies. Chembiochem 15, 1573-7.

Johnson SF, Collins JT, D’Souza VM, Telesnitsky A (2014). Determinants of Moloney murine leukemia virus Gag-Pol and genomic RNA proportions. J. Virol. 88, 7267-75.

Durney MA, D’Souza VM (2013). HIV-1: Packaging a Shifty Genome? Cell Host & Microbe 13, 123-125.

Houck-Loomis B, Durney MA, Salguero C, Shankar N, Nagle JM, Goff SP, D’Souza VM (2011). An equilibrium-dependent retroviral mRNA switch regulates translational recoding. Nature 480, 561-4.

Durney MA, D’Souza VM (2010). Preformed protein-binding motifs in 7SK snRNA: structural and thermodynamic comparisons with retroviral TAR. J. Mol. Biol. 404, 555-67. [Cover article]

Miyazaki Y, Irobalieva RN, Tolbert BS, Smalls-Mantey A, Iyalla K, Loeliger K, D’Souza V, Khant H, Schmid MF, Garcia EL, Telesnitsky A, Chiu W, Summers MF (2010). Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography. J. Mol. Biol. 404, 751-72.

D’Souza V, Summers MF (2005). How retroviruses select their genomes. Nature Rev. Microbiol. 3, 643-55. Review.

D’Souza V, Summers MF (2004). Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus. Nature. 431, 586-90.

D’Souza V, Dey A, Habib D, Summers MF (2004). NMR structure of the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus. J. Mol. Biol. 337, 427-42.

D’Souza V, Melamed J, Habib D, Pullen K, Wallace K, Summers MF (2001). Identification of a high affinity nucleocapsid protein binding element within the Moloney murine leukemia virus Psi-RNA packaging signal: implications for genome recognition. J. Mol. Biol. 314, 217-32.