Featured Publications

Pham VV, Salguero C, Khan SN, Meagher JL, Brown WC, Humbert N, de Rocquigny H, Smith JL, D’Souza VM (2018). HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry. Nature Communications 9. Departmental Feature.


Imai S, Kumar P, Hellen CU, D’Souza VM, Wagner G (2016). An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation. Nature Structural & Molecular Biology 23, 859-864.

Longhini AP, LeBlanc RM, Becette O, Salguero C, Wunderlich CH, Johnson BA, D’Souza VM, Kreutz C, Dayie TK (2016). Chemo-enzymatic synthesis of site-specific isotopically labeled nucleotides for use in NMR resonance assignment, dynamics and structural characterizations. Nucleic Acids Res. 44, e52.

Miller S, Yildiz FZ, Wang B, Lo J, D’Souza VM (2014). A structure-based mechanism for tRNA and retroviral RNA remodelling during primer annealing. Nature 515, 591-5.

Alvarado LJ, LeBlanc RM, Longhini AP, Keane SC, Jain N, Yildiz ZF, Tolbert BS, D’Souza VM, Summers MF, Kreutz C, Dayie TK (2014). Regio-selective chemical-enzymatic synthesis of pyrimidine nucleotides facilitates RNA structure and dynamics studies. Chembiochem 15, 1573-7.

Johnson SF, Collins JT, D’Souza VM, Telesnitsky A (2014). Determinants of Moloney murine leukemia virus Gag-Pol and genomic RNA proportions. J. Virol. 88, 7267-75.

Durney MA, D’Souza VM (2013). HIV-1: Packaging a Shifty Genome? Cell Host & Microbe 13, 123-125.

Houck-Loomis B, Durney MA, Salguero C, Shankar N, Nagle JM, Goff SP, D’Souza VM (2011). An equilibrium-dependent retroviral mRNA switch regulates translational recoding. Nature 480, 561-4.

Durney MA, D’Souza VM (2010). Preformed protein-binding motifs in 7SK snRNA: structural and thermodynamic comparisons with retroviral TAR. J. Mol. Biol. 404, 555-67. [Cover article]

Miyazaki Y, Irobalieva RN, Tolbert BS, Smalls-Mantey A, Iyalla K, Loeliger K, D’Souza V, Khant H, Schmid MF, Garcia EL, Telesnitsky A, Chiu W, Summers MF (2010). Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography. J. Mol. Biol. 404, 751-72.

D’Souza V, Summers MF (2005). How retroviruses select their genomes. Nature Rev. Microbiol. 3, 643-55. Review.

D’Souza V, Summers MF (2004). Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus. Nature. 431, 586-90.

D’Souza V, Dey A, Habib D, Summers MF (2004). NMR structure of the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus. J. Mol. Biol. 337, 427-42.

D’Souza V, Melamed J, Habib D, Pullen K, Wallace K, Summers MF (2001). Identification of a high affinity nucleocapsid protein binding element within the Moloney murine leukemia virus Psi-RNA packaging signal: implications for genome recognition. J. Mol. Biol. 314, 217-32.